Living with cancer is one of the greatest challenges you will ever face.

Still, this was the greatest challenge I could ever face in my career, and maybe one too great.

I think this is the greatest challenge of his career.

Don't give up and lose the greatest challenge of your life.

We didn't want to fail now in the face of our greatest challenge.

But the greatest challenge may be on the business side.

"That is probably the greatest challenge to the space station program."

He would not back down from this greatest challenge of all.

This perhaps is the greatest challenge we face as a Community.

Making this clear to people is perhaps the greatest challenge that we must meet together.