Early records also have a substantial uncertainty driven by systematic concerns over the accuracy of sea surface temperature measurements.

And, right now at least, there's substantial uncertainty as to whether that will happen.

If an approach is really novel, there is likely to be a substantial uncertainty in its prospects.

So aerosol forcing is another substantial uncertainty in predictions of future climate.

There is, of course, substantial uncertainty about this figure.

Chapters said the hostile bid was inadequate and created substantial uncertainties for shareholders.

There are substantial uncertainties in the measurement of net carbon emissions.

Because of this substantial uncertainty, most legal theorists find the theory to be unworkable in practice.

But the science of this change appears to be complex and probably subject to substantial uncertainty.

Though substantial uncertainties exist in the estimates, these are nonetheless startling revelations.