By now, however, a substantial change had taken place from those earlier days.

More substantial changes are made toward the end of the story.

Substantial changes were made to the house in the 1830s.

It is early yet to be sure of substantial change.

White did not design the house but made substantial changes while living there.

The hundred years had really made substantial changes in all of them.

There have been no other substantial changes to the building.

I therefore feel that the time has come for substantial changes.

While the school would not see any substantial changes until the early 2010s, planning began several years earlier.

However, the 1999 Act did not make substantial changes to the profession.

He added, though, that "the board and management know substantial change is needed."

A more substantial change came over time to the show's target audience.

By May 2007, there had been fundamental and substantial changes made to the game.

After all, only a substantial change in the major institutions of the State will be able to bring back peace to that country.

They agree that the health care system requires substantial change.

Each requires substantial change in the way we think and function.

Substantial changes are already taking place in the postal market.

During tests, there were not substantial changes in deep sleep.

Scott proposed to make substantial changes to the building's design.

There is evidence of substantial change in indigenous culture over time.

We are making substantial changes within the system, which I will reveal in due course.

For all his moderation, he has already brought substantial change.

Having made substantial changes, the group has satisfied many of its critics.

There needs to be a substantial change in government policy towards service organisations.

"These products lead to companies making very substantial changes in their governance."