This was a difficult decision, and came with significant risk.

And there is a significant risk that they will have lifelong health problems.

He did his best and put himself at significant risk.

Your general health places you at significant risk from having any kind of surgery.

There is, therefore a significant risk of serious injury especially to small children.

There were significant risks in taking that action, of course.

What does it matter if there are significant potential risks to human health and the environment?

It takes about an hour, and there are no significant risks or side effects.

Apparently she had asked him to take a significant risk.

As a group, they face a significant risk for lifelong problems.