Vabicaserin is a full agonist with approximately 4-fold more selective for 5-HT, over these related receptors in terms of binding affinity.
The κ-opioid receptor is one of five related receptors that bind opium-like compounds in the brain and are responsible for mediating the effects of these compounds.
That search led them to discover a family of closely related receptors far bigger than they had expected.
However with modern molecular biology techniques such as screening of cDNA libraries, it becomes possible to identify related receptors based on sequence similarity to known receptors without knowing what their ligands are.
Poretsky and his coworkers also characterized related receptors in the ovary (insulin-like growth factor receptors, peroxisome-proliferator activated receptor-gamma), and he conceptualized an insulin-related ovarian regulatory system.
Steroid hormone receptors and related receptors are generally soluble proteins that function through gene activation.
BRL-15,572 is a drug which acts as a selective antagonist for the serotonin receptor subtype 5-HT, with around 60x selectivity over other related receptors.
It has been proposed that the MAGE conserved domain of MAGE-D proteins might interact with p75 neurotrophin or related receptors.
The most closely related receptor to the 5-HT is the 5-HT receptor.
Their analysis identified several significant linkage peaks and the associated chromosomal regions implicate a possible role for NMDA and glutamate related receptors in forming political attitudes.
