What does a lad like him know of such matters?

"What can a little country girl know of such matters?"

What can you, a male, possibly know of such matters?

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"I find it difficult to sympathize with his fate, but neither I nor anyone in my family know of such matters."

She may give you a chance to explain and what I know of such matters leads me to think you had better grovel.

"What does this man know of public matters?"

What did she know of such silly matters?

"Who am I that I should know of such matters?"

You know far more of military matters than do I, alas.