Another event of that sort would be a significant blow to the accounting board's credibility.

"The loss of even one animal represents a significant blow," he said.

The loss of this commander was a significant blow to the English.

This is most certainly going to be another significant blow to them.

The rating changes are not expected to be a significant blow to the company.

But the move is a significant blow to Oracle, the world's second largest software company.

Relief experts say that was a significant blow to the organization from its largest member.

Failure to take either of these steps would be a significant blow to our economy.

This has already led to significant blows to state efforts to protect endangered species.

In either case, its a significant blow to the player's cash.