In a profound sense, this son of the 50's is running against history.

And for me there was a profound sense of mourning.

He felt only a profound sense of having come home.

I felt a profound sense of loneliness during my high school and early college years.

And this is the first time, to my knowledge, that one has created something in the more profound sense of the word.

We share with our colleagues in the health care world a profound sense of loss.

They have a profound sense of what their duty should be.

I had a deep and profound sense of having made a wrong choice.

I think he has a profound sense of being alone.

But the two failed in a more profound sense as well.