His problems are not merely a result of personal insanity, without larger significance.

It is possible that the "doorway to death" name has a much larger significance.

The better homicides also offer the potential for larger significance.

But the larger significance is a psychological breakthrough that goes beyond numbers.

He had not realized that humans attached large significance to the word before.

"Is not really a matter of any large significance entirely," he said.

Of course, there was larger political significance in this judicial race.

Teams like Alabama's don't just represent 11 men on the field; they have far larger cultural significance.

These choices would soon come to have large political significance.

These pale next to the larger significance of the treaty.