This is quite a large assumption that's being made.

And that's making the rather large assumption that it is ever relevant at all.

'Wanting to kill you seems to me a very large assumption,' he said.

But equally flawed were the larger political assumptions about who was behind the anthrax attacks.

There are a couple of very large assumptions in their model.

But to do that, we had to make some rather large assumptions.

"A large and foolish assumption," Medric said as he turned away.

This move rests on a large assumption that is almost universally held, although it is certainly false.

Assuming (and it is a large assumption) that he or she would be able to find the way at all.

And that seems to be too large an assumption.