I have started irreversible changes of a nature you know well.

But she also acknowledged that the country is going through what appear to be irreversible changes.

The fundamental question is whether a third or fourth Thatcher term would produce irreversible changes.

The one iron law is that you may not write irreversible changes to a character without the consent of the person who 'owns' it.

It won't be 'irreversible change' though if the mass of the public stand their ground and have their way.

But they said the evidence showed that global warming would bring major, irreversible changes in the country's natural systems.

Far more important than this change, though, is the irreversible change in the character of universities.

However, once agriculture is adopted by a society there are many irreversible changes.

Significant and possibly irreversible changes have already taken place.

Almost all of their violations brought irreversible change, sometimes complete destruction to an entire culture.