Whatever it was, it couldn't interbreed with us; gross differences in the number of chromosomes.

Oh, sure, if there's some minor variation that makes no gross difference, meaning can still be conveyed.

Such gross differences are easy to point out.

Oh, they recognized the gross differences of age and gender, but the subtler distinctions were hard to see.

'It is one of gross and fundamental difference in the quality of the safety approach.'

"But this is a rather gross anatomical difference, and that's a dramatic finding."

Strange (though perhaps only to her nonmilitary view) how very similar the military minds were to each other, despite gross difference in physical format.

We start from the gross difference in size of the male and female gamete.

But despite this gross difference between the frames, parallelism persisted; people tended to align.

Sometimes there are gross differences in testimony, say, about a bridge collapse.