This is the functional definition of state one; it is its causal role in the overall system.

The presence of these clumps was once thought to play a causal role in Huntington disease.

These were termed severe events and were assumed to have a causal role.

This encouraged the authors to argue for some causal role for these specific event types.

This means that family and school problems may be common antecedents of schizophrenia, but have no causal role in bringing it about.

The causal role of different socioeconomic factors may vary by country.

Etiologic fraction is the proportion of the cases that the exposure had played a causal role in its development.

Experimental evidence is needed to definitively establish the causal role of soft drink consumption.

They must be accorded a permissive rather than a causal role.

The City of London is set, once again, to play a major causal role in the coming financial catastrophe.