These agents reduce the aggregation ("clumping") of platelets by irreversibly binding to P2Y receptors.

Azide inhibits cytochrome oxidase by binding irreversibly to the heme cofactor in a process similar to the action of carbon monoxide.

As it binds irreversibly to the pumps, new pumps have to be made before acid production can be resumed.

Avidin binds irreversibly to biotin and this compound is then excreted in the urine.

Malathion is an organophosphate parasympathomimetic which binds irreversibly to cholinesterase.

It might be explained by the fact that the toxin is effective from the luminal side and binds irreversibly to a particular membrane receptor.

The antibiotic penicillin irreversibly binds to and inhibits the activity of the transpeptidase enzyme by forming a highly stable penicilloyl-enzyme intermediate.

As described above, the active form will covalently and irreversibly bind to the gastric proton pump, deactivating it.

The transport proteins associated with the root also can irreversibly bind and stabilize target contaminants.

Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity.