transversion

Therefore, 26.4 transversions was an underestimate of the likely number of transversion events.

This mutation can be a deletion, transition, insertion, or transversion.

A transversion (T G) mutation is the most common among adults with this disorder.

By contrast, an exchange between one purine and one pyrimidine is called a transversion.

An example of a transversion is adenine (A) being converted into a cytosine (C).

The first mutation is the transversion of gene from C to G causing a premature stop signal in the protein.

First published in Issue Three of TransVersion (October 1995).

In molecular biology, transversion refers to the substitution of a purine for a pyrimidine or vice versa.

Methods that account for biases in codon usage and transition/transversion rates are substantially more reliable than those that do not.

Autosomal dominant sectoral retinitis pigmentosa: two families with transversion mutation in codon 23 of rhodopsin.

However the sequencing of Feldhofer I Neanderthal revealed that there was also a transversion between humans and Neanderthals at this site.

Ocular findings associated with a rhodopsin gene codon 58 transversion mutation in autosomal dominant retinitis pigmentosa.

In single stranded DNA, cytosine spontaneously slowly deaminates to adenosine (a C to A transversion).

The single most frequent mutation is in the BRAF gene, with 60% to 70% of malignant melanomas harboring a single nucleotide transversion.

A third mutation (a transversion) in this gene has also been described - G145T (Alanine49 Serine) - that has been associated with the Fy-x phenotype.

Less common is a transversion, which exchanges a purine for a pyrimidine or a pyrimidine for a purine (C/T A/G).

The most common mutation is A149P, which is a guanine to cytosine transversion in exon 5, resulting in the replacement of alanine at position 149 with proline.

His friends teased him on the peculiarities of his diction, which James Mackintosh styled the Taylorian language: he coined words such as 'transversion,' 'body-spirit,' and 'Sternholdianism.

A transition to transversion ratio was applied to this distance to estimate sequence divergence in the HVR between chimpanzees and humans, and divided by an assumed T of 4 to 6 million years.

We have confirmed the molecular mutation of the y 1allele as an A to C transversion in the ATG translation initiation codon as first determined by Geyer et al. [ 28].

"Transversion" is the term used to indicate the slower-rate substitutions that change a purine to a pyrimidine or vice versa (A C, A T, G C, and G T).

APOBEC3G is a cytidine deaminase against single stranded DNA which introduces transversion mutations into the HIV genome during reverse transcription by randomly changing cytidine basepairs into uracil.

By inducing G (guanine) to T (thymidine) transversions in transversion hotspots within p53, there is a probability that benzo[a]pyrene diol epoxide inactivates the tumor suppression ability in certain cells, leading to cancer.

Depurinated bases in single-stranded DNA undergoing replication can lead to mutations, because in the absence of information from the complementary strand, BER can add an incorrect base at the apurinic site, resulting in either a transition or transversion mutation.

In 1980 Kimura introduced a model with two parameters: one for the transition and one for the transversion rate and in 1981, Felsenstein proposed a four-parameter model in which the substitution rate corresponds to the equilibrium frequency of the target nucleotide.