In the kidney it is made by proximal convoluted tubule cells.

The first segment of these tubules is the proximal convoluted tubule.

At the urinary pole, the proximal convoluted tubules arises.

Proximal convoluted tubule: It then may reabsorb urea in the thick descending limb.

The urinary pole is where the corpuscle opens into the lumen of the proximal convoluted tubule.

It is now established that insulin has an antinatriuretic action resulting in increased sodium reabsorption probably from the proximal convoluted tubules.

Under normal conditions nearly all the glucose removed in the glomerulus is reabsorbed in the proximal convoluted tubule.

Fluid in the filtrate entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries.

Hypovolemia may increase the reabsorption of calcium and bicarbonate in the proximal convoluted tubules of the kidney.

The initial symptoms are those of a tubulo-interstitial nephritis of the sort met with after toxic aggressions to the proximal convoluted tubules.

As a result, the filtrate leaving the Bowman's capsule is very similar to blood plasma in composition as it passes into the proximal convoluted tubule.

The distal convoluted tubule has a different structure and function to that of the proximal convoluted tubule.

Proximal convoluted tubule (lies in cortex and lined by simple cuboidal epithelium with brushed borders which help to increase the area of absorption greatly.)

Histologically, cells of the DCT can be differentiated from cells of the proximal convoluted tubule:

Firstly, the glucose in the proximal tubule is co-transported with sodium ions into the proximal convoluted tubule walls.

Carbonic anhydrase inhibitors inhibit the enzyme carbonic anhydrase which is found in the proximal convoluted tubule.

The DCT is lined with simple cuboidal cells that are shorter than those of the proximal convoluted tubule (PCT).

It acts in the kidneys, at the proximal convoluted tubule (PCT) of the nephron where it inhibits the sodium-chloride symporter.

In BEN renal biopsy shows acellular interstitial fibrosis, tubular atrophy, karyomegaly in proximal convoluted tubules.

Loop of Henle: the long U-shaped part of the renal tubule, extending through the medulla from the end of the proximal convoluted tubule.

The descending loop of Henle receives isotonic (300 mOsm/L) fluid from the proximal convoluted tubule (PCT).

Researchers at MIT claim to have designed a bioartificial device that replicates the function of the nephron's glomerulus, proximal convoluted tubule and loop of Henle.

This leads to a decreased ability to exchange Na for H in the presence of acetazolamide (in proximal convoluted tubules of kidney) resulting in a mild diuresis.

The excess hemoglobin is filtered by the kidney and reabsorbed in the proximal convoluted tubule, where the iron portion is removed and stored in ferritin or hemosiderin.

PAH remaining in the vasa recta or peritubular capillaries is taken up actively by epithelial cells of the proximal convoluted tubule and secreted into the tubular lumen.