With a high value, proton transfer in the transition state is almost complete.
In fact in 2002 the compound was found to be more stable and to exist as the zwitterion after a proton transfer.
The contributions of proton transfer followed by electrolytic dissociation were resolved by these studies.
This reaction cannot be described in terms of Brønsted theory because there is no proton transfer.
The rather complex two-step mechanism by which this occurs is important, as it increases the efficiency of proton transfer.
In dense clouds, proton transfer with CO is the dominating destruction mechanism.
The conserved glutamic acid residue at position 97 is involved in the catalytic proton transfer.
Looking at the extent of proton transfer over the course of the reaction is challenging and has not been investigated thoroughly in most reactions.
This is due to intramolecular hydrogen bonding and possibly to an easy internal proton transfer.
Protic solvents also mediate the proton transfer during the tautomerisation.