Egleston became the first professor of mineralogy and metallurgy in 1864, and held that position until his death.

In 1844 be became professor of geology and mineralogy at Rennes.

In 1810 he became a professor of mineralogy at the University of Berlin.

In 1845 he was appointed professor of mineralogy also, and held both chairs till 1878, when ill-health obliged him to resign.

In 1885 he was made professor of mineralogy at the University of Greifswald.

In 1890, he became the professor of chemistry and mineralogy at Oberlin College.

In the same year, largely through his influence, the university of Bern was established and he became the first professor of mineralogy.

In 1849 he gave up his medical practice, and became professor of mineralogy at the university of Prague.

He ended his career as professor of geology and mineralogy at Adelaide University.

In 1876, he became a professor of chemistry and mineralogy at the Sorbonne.