The global financial crisis has had a large impact on America.
It is well known that changes in energy costs have a large impact on economic growth rates.
We think that big data is going to have a large impact on 2012.
"It's one that has a large impact on the way we run our schools."
A relatively small change in the interest rate can have a large impact.
Mining has had a large impact on the growth of the area.
The series made a large cultural impact, which continues today.
D&D also had a large impact on modern video games.
The plan could have a larger impact than his cuts.
Environmental conditions can have a large impact on this plant.