These are particularly troublesome as not only do they induce physical and psychological dependence, but users also develop tolerance to them.

Nonbenzodiazepines are contraindicated during benzodiazepine withdrawal as they are cross tolerant with benzodiazepines and can induce dependence.

While addiction does not seem to be an issue with this class of drugs, they can induce dependence and rebound effects upon abrupt cessation of use.

When taken in excess alcohol causes liver damage, blood sugar problems, impaired brain function, and induces dependence.

Opiates, benzodiazepines, barbiturates, alcohol and nicotine induce physical dependence.

Quote from abstract: "These data suggest that etizolam is endowed with a reduced liability to induce tolerance and dependence compared with classical benzodiazepines."

Nevertheless, the prescribing information for Ultram warns that tramadol "may induce psychological and physical dependence of the morphine-type".

Sedative-hypnotics, such as alcohol, are well known for their propensity to induce physiological dependence.

Benzodiazepines can be addictive and induce dependence even at low doses, with 23% becoming addicted within 3 months of use.

He specifically screened Delphinium denudatum for its protective activity in morphine induced physical dependence.