This study included male patients and appropriate controls recruited in different European populations at highly contrasting risk for coronary heart disease.

Podsols in boreal forests have highly contrasting layers due to acidity and leaching.

But this was a game that cried out for the introduction of the big men, and eventually it got three of them, with highly contrasting results.

Unlike a typical sonata, this piece consists of two highly contrasting movements:

Hardy and Ramanujan had highly contrasting personalities.

Mr. Doyle uses highly contrasting and deeply saturated color.

The work is in two highly contrasting movements:

In contrast to a strong preference for similar color combinations, some people like to accent with a highly contrasting color.

The retinal implant allows patients to distinguish between highly contrasting light and dark images.

In both these cases, the following movement contains highly contrasting music.