Connolly Hospital served as such a facility until the advent of more efficacious antibiotic treatment in the 1960s and 1970s.

During all the 20th century there was an important development on the theories about the cause and pathogenesis of MS while efficacious treatments began to appear in 1990.

The fear of rabies was almost irrational, due to the significant number of vectors (mostly rabid dogs) and the absence of any efficacious treatment.

Interventions are assigned to Category 2, supported and probably efficacious treatment, based on positive outcomes of nonrandomized designs with some form of control, which may involve a non-treatment group.

Whether or not valerian is an efficacious treatment for insomnia is still a very open question.

Although newer and more efficacious treatments for heart failure are available, digitalis compounds are still used.

All types of 'safe household water storage must be used with water from known clean sources or with water having received prior efficacious treatment.

Based on the 1994 study, a textbook on evidence-based adjunctive treatments lists TM as a "probably efficacious" treatment for alcohol abuse disorder.

Gemmotherapy, like many other alternative therapies, lacks an evidential basis and is not accepted as an efficacious treatment by the scientific community.

No study has found them to be efficacious treatments in preventing relapse.