In at least some Kir's, these cytoplasmic domains modulate the activity of the channel.
There is evidence to suggest that the main pH sensor is in the cytoplasmic domain.
The transmembrane and cytoplasmic domains have 17 and 145 amino acids respectively.
Teloblasts have two separate cytoplasmic domains: the teloplasm and the vitelloplasm.
In contrast, the cytoplasmic domain tends to have high sequence homology and contains several well-known motifs.
The cytoplasmic domain has specific regions where catenin proteins bind.
It has been shown that the reason for this difference lies in the cytoplasmic domain.
Removal of the cytoplasmic domain abolish the motility of the parasite.
Their cytoplasmic domains interact with the cell cytoskeleton to anchor them.
The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins.