The disorder is progressive and, in some cases, may result in chronic respiratory failure.

COPD is a common and costly lung disease whose advanced stage is chronic respiratory failure.

Death may occur suddenly from acute pulmonary haemorrhage or after progressive pulmonary insufficiency resulting in chronic respiratory failure.

Gorō Naya, 83, Japanese voice actor (Lupin III, Kamen Rider, Space Battleship Yamato), chronic respiratory failure.

Nasal intermittent positive pressure ventilation (NIPPV) has been used in patients with acute and chronic respiratory failure due to neuromuscular disease, chest wall deformities, COAD, cystic fibrosis, and obstructive sleep apnoea.