And this change has a big downside: it's no longer possible to just turn on 6to4 and start experimenting.

The biggest downside to the 200B was the noise the driver would have to endure.

Not having Flash is not a big downside as it once was.

What puts you at risk This suppression of the immune system has a big downside, however.

The big downside to the accounts is that they have lower contribution limits.

The big downside of people's war is that the whole people then become subject to retaliation (p. 81).

Perhaps the biggest downside to mergers, however, is their human toll.

"Most of my patients don't see that as a very big downside."

However, I think I've discovered one big downside to it.

The biggest downside of the market is Italy's brittle political situation.