tragic flaw
hamartia

Now he finds his handiwork threatened by that system's tragic flaw.

The hero had to have a tragic flaw, had to drive himself to his fate.

I mean hero as in he whose tragic flaws will be his undoing.

Yeah, Tony, and our tragic flaw is adherence to human rights.

To her, his tragic flaw was simply being too trusting.

Perhaps the lack of imagination had always been the tragic flaw.

We must face the unpleasant reality that otherwise good, even great, people may harbor tragic flaws.

"It's the chief's tragic flaw," he said in an interview.

Could I fool myself into believing that he'd forgive me for what he saw as an obvious tragic flaw?

As Picard watched, he saw before him a man who was his own tragic flaw.