The Perote ground squirrel (Xerospermophilus perotensis) is a species of rodent in the Sciuridae family.

Franklin's ground squirrel is suggested to be sister to a clade containing not only the Mohave, round-tailed, spotted, and Perote ground squirrels (genus Xerospermophilus), but the prairie dogs as well.

Within the genus, the Mohave ground squirrel and the round-tailed ground squirrel were thought to be close relatives, sometimes a subgenus Xerospermophilus, while the spotted ground squirrel and the Perote ground squirrel were placed in the subgenus (now a genus) Ictidomys.