vitelliform macular dystrophy
dystrophia maculae vitelliformis latin

Researchers have described two forms of vitelliform macular dystrophy with similar features.

It can be associated with Vitelliform macular dystrophy.

Vitelliform macular dystrophy does not affect side (peripheral) vision or the ability to see at night.

The inheritance pattern of adult-onset vitelliform macular dystrophy is uncertain.

Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy.

Best vitelliform macular dystrophy is associated with an abnormality in the VMD2 gene.

The two forms of vitelliform macular dystrophy each have characteristic changes in the macula that can be detected during an eye examination.

Vitelliform macular dystrophy causes a fatty yellow pigment (lipofuscin) to build up in cells underlying the macula.

Mutations in the PRPH2 gene are associated with Vitelliform macular dystrophy.

Vitelliform macular dystrophy or vitelliform dystrophy is a genetic eye disorder that can cause progressive vision loss.

Mutations in the RDS and VMD2 genes cause vitelliform macular dystrophy.

It is unclear why RDS mutations affect only central vision in people with adult-onset vitelliform macular dystrophy.

In addition, Best vitelliform macular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.

Changes in either the VMD2 or RDS gene can cause the adult-onset form of vitelliform macular dystrophy; however, fewer than a quarter of cases result from mutations in these two genes.