Boylston went on to variolate thousands of Massachusetts residents, and many places were named for him in gratitude as a result.

Lady Montagu encouraged the Princess of Wales to variolate her two daughters.

On her return to London, she asked Maitland to variolate her four-year-old daughter in the presence of the king's physicians.

With the support of Mather, Boylston went on to successfully variolate 300 patients with only six of them dying.

Determined to spare her five-year-old son Edward from similar suffering, she ordered the embassy surgeon Charles Maitland to variolate him.

Thomas Dimsdale, a prominent banker, politician, and physician, was invited to visit St Petersburg to variolate Catherine the Great.

In 1768, perhaps due to his prominence in London society, he was invited to St Petersburg to variolate the Empress Catherine the Great of Russia.