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Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis.
These include etanercept (which is the soluble receptor for TNF.
Release of the receptor may also generate soluble receptors which act as decoys by sequestering ligands.
In similar manner, the gene for IL-17RD may undergo alternative splicing to yield a soluble receptor.
Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity ".
The M-T2 protein is a soluble receptor the mimics the TNF receptors within rabbits.
One independently validated nomogram demonstrated increased accuracy in predicting biochemical recurrence-free survival by including preoperative plasma levels of transforming growth factor B1 and interleukin-6 soluble receptor.
Kendall R, Thomas K. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.
Similarly, when faced with another type of social stress, namely social evaluative threat, participants showed increases in IL-6 and a soluble receptor for tumor necrosis factor-α [61-63].
Activation and deactivation results from a variety of factors, including cytokines, soluble receptors, arachidonic acid metabolites, steroids, receptor antagonists, adhesion molecules, bacterial products and viral products.
HSPLs (phage clones or synthetic peptides) are added in the presence of varying concentrations of competitor (e.g., TNF ligand or soluble receptor).
FcεRII has multiple functions as a membrane-bound or soluble receptor; it controls B cell growth and differentiation and blocks IgE-binding of eosinophils, monocytes, and basophils.
ApoER2 moreover, can harbour a cleavage site for the protease furin between type A and type B repeats which enables production of a soluble receptor fragment by furin-mediated processing.
IL-17RC is expressed by the prostate, cartilage, kidney, liver, heart, and muscle, and its gene may undergo alternate splicing to produce a soluble receptor in addition to its cell membrane-bound form.
Warzocha K, Bienvenu J, Ribeiro P, et al.: Plasma levels of tumour necrosis factor and its soluble receptors correlate with clinical features and outcome of Hodgkin's disease patients.
Because OPG is a soluble receptor for TRAIL [ 58 ] , S. aureus -induced TRAIL secretion could have a profound effect on both osteoblasts and osteoclasts.
DcR3 is a soluble receptor that has no signal transduction capabilities (hence a "decoy") and functions to prevent FasR-FasL interactions by competitively binding to membrane-bound Fas ligand and rendering them inactive.
Kattan MW, Shariat SF, Andrews B, et al.: The addition of interleukin-6 soluble receptor and transforming growth factor beta1 improves a preoperative nomogram for predicting biochemical progression in patients with clinically localized prostate cancer.