In experiments with rats, increased electrical activity was recorded in the satiety centre of the brain during chewing and swallowing.

The major control mechanisms appear to be the state of fullness of the stomach, the level of sugar in the blood, and a satiety centre in the brain known as the appestat.

The satiety center in animals are located in ventromedial nucleus of hypothalamus.

In experiments with rats, increased electrical activity was recorded in the satiety centre of the brain during chewing and swallowing.

This strongly substantiates the classification of VMN as the primary satiety center in the hypothalamus.

Glucostatic hypothesis: the activity of the satiety center in the ventromedial nuclei is probably governed by the glucose utilization in the neurons.

When sufficient food or substrates have been received and leptin is high, then the satiety center is stimulated and sends impulses that inhibit the feeding center.

The major control mechanisms appear to be the state of fullness of the stomach, the level of sugar in the blood, and a satiety centre in the brain known as the appestat.

The anorectic properties of GLP-1 and its peptide analogs are thought to be due in part to both inhibition of gastric emptying and deactivation of central satiety centers coupled with reduction of energy intake.

The circuit begins with an area of the hypothalamus, the arcuate nucleus, that has outputs to the lateral hypothalamus (LH) and ventromedial hypothalamus (VMH), the brain's feeding and satiety centers, respectively.

A recent suggestion is that there are two appetite-controlling centers: one to turn it on (a "feeding center") and one to turn it off (a "satiety center"), and that it is the latter which is often malfunctioning in the somewhat overweight person.