Upon meeting the waterway, NY 383 begins to run along the Genesee River's western bank to a junction with NY 252.

At this junction, F-97 merges with M-18 and the two roads run due north to a junction with M-72 west of Luzerne.

The road runs from Norwich to a junction with the A149 near Smallburgh.

The route then follows the Old Fredericton Road, running due west to a junction with Route 885 at New Canaan.

At one time it is thought that there were two Roman waterways that ran to a junction within the parish.

In Otsego, NY 205 continues to run through mostly undeveloped areas to a junction with NY 80.

The route runs northeast to a junction with Highway 7 outside Smackover before entering the city limits.

It was located on a local line which ran from Malton to a junction with the Pickering to Thirsk line at Gilling.

The route continues on, running along the southwestern edge of Fort Drum to a junction with NY 283.

It runs from a junction near Mildenhall, to a junction on the western outskirt of Fakenham.