Polyanhydrides are synthesized using either melt condensation or solution polymerization.

Traditionally, polyanhydrides have been prepared by melt condensation polymerization, which results in high molecular weight polymers.

Sold under the tradename Bionolle, these polyesters are synthesized via melt condensation polymerization followed by a chain-extension with a diisocyanate.

Melt condensation polymerization involves reacting dicarboxylic acid monomers with excess acetic anhydride at a high temperature and under a vacuum to form the polymers.