Leukine is one of a revolutionary new class of drugs called granulocyte macrophage-colony stimulating factor drugs, analysts say.

Spontaneous recovery from SSZ agranulocytosis is frequently seen, although fatalities have been reported and some patients may benefit from granulocyte macrophage-colony stimulating factor [ 39 40 ] .

The c- fms gene encodes the receptor for the macrophage-colony stimulating factor (M-CSF) which promotes the proliferation and survival of cells of the monocytic lineage (1).

In this regard, recent studies have shown that inflammatory mediators such as lipopolysaccharide (LPS), granulocyte macrophage-colony stimulating factor and leukotriene B 4 delay apoptosis and prolong neutrophil survival in culture [ 3 4 ] .

As of October 2012, its most advanced drug candidate is MOR103, a fully human HuCAL antibody directed against GM-CSF (granulocyte macrophage-colony stimulating factor), developed in the area of inflammatory diseases, i.e. rheumatoid arthritis.