The high cost of GnRH analogues is often a significant factor.

This is called pituitary down-regulation with a GnRH analogue.

But when GnRH analogues are taken alone, they produce a temporary condition similar to menopause, with many of the same effects.

When paired with ovulation-stimulating treatment, GnRH analogues don't cause low-estrogen symptoms.

Also, some skeletal changes (such as increased height), which may be considered masculine, are not hindered by GnRH analogues.

Some GnRH analogues are taken as nasal sprays and some are injected under the skin.

To treat infertility concerns, a GnRH analogue (agonist or antagonist) is used:

GnRH analogues (agonists and antagonists) predictably stop ovulation and menstruation.

All GnRH analogues are contraindicated in pregnancy (pregnancy category X).

GnRH analogues are often prescribed to prevent the reactivation of testicular function where surgeons require the cessation of estrogens prior to surgery.

Gonadotropin-releasing hormone (GnRH) agonists and antagonists belong to a group of hormone drugs called GnRH analogues.

There have been studies to investigate the benefit of adding an anti-androgen to surgical orchiectomy or its continued use with a GnRH analogue (combined androgen blockade, CAB).

Namely in genetic females presenting with ovarian cysts, GnRH analogues may be used to control high FSH and LH levels if they are unresponsive to estrogens.

A GnRH analogue is designed to interact with the GnRH receptor and modify the release of pituitary gonadotropins FSH and LH for therapeutic purposes.

Kaisary AV, Tyrrell CJ, Peeling WB, et al.: Comparison of LHRH analogue (Zoladex) with orchiectomy in patients with metastatic prostatic carcinoma.

Reversal of clinical resistance to LHRH analogue in metastatic prostate cancer by the pineal hormone melatonin: efficacy of LHRH analogue plus melatonin in patients progressing on LHRH analogue alone.