Production of these endogenous opioids is increased during the birthing process.

Other neurons can release their endogenous opioids at the source of the pain, as well.

The body senses the increased blood pressure, and it is hypothesized that in response, endogenous opioids are released.

It may be that in various painful and other unpleasant conditions animals deal with them by an increased usage of endogenous opioids.

Sexual motivation: Involvement of endogenous opioids in the ventral tegmental area.

There are indications that self-narcotisation is a method which animals can use to cope with difficulties using endogenous opioids.

They found that endogenous opioids, such as dynorphin, stimulate appetite and decrease energy expenditure.

The importance of brain peptides became clearer with the discovery of endogenous opioids.

State-dependent changes of brain endogenous opioids in mammalian hibernation.

Endogenous opioids are types of opioids produced by the body specifically to modulate pain.

Some of the analgesic (painkilling) effect of placebo treatment is due to endogenous opioids, ones made by the body.

The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin.

Diisopropyl phosphofluoridate-induced antinociception: possible role of endogenous opioids.

In vertebrates, endogenous opioids are neurochemicals that moderate pain by interacting with opiate receptors.

(It has been known that placebo analgesia depends upon the release in the brain of endogenous opioids since 1978.)

Drugs which inhibit the breakdown of endogenous opioids also potentiate the antinociceptive effects of NO.

Endogenous opioids, such as endorphin and dynorphin, are natural chemicals, related to the opium molecule, that are produced in the central nervous system.

The body possesses an additional mechanism to control pain: the release of endogenous opioids, especially at the level of the PAG.

Involvement of endogenous opioids and their receptors in the regulation of colonic transit was proposed by Kreek but further investigation failed to confirm this.

It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin.

Dry needling that elicits LTRs improves treatment outcomes, and may work by activating endogenous opioids.

Mandenoff et al. proposed that, although endogenous opioids are not necessary to maintain body weight and energy expenditure under predictable circumstances, they become activated under stressful conditions.

Administration of antibodies which bind and block the activity of some endogenous opioids (not β-endorphin) also block the antinociceptive effects of NO.

While there is some evidence that placebo interventions can alter levels of hormones or endogenous opioids, other prominent components include expectancy effects, regression to the mean, and flawed research methodologies.

The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids.