cyclins

"To go from one stage to the next, you need to get rid of these cyclins very suddenly."

At some point, the signal must ignite the rapid production of cyclins.

Its role turned out to be to block cyclins so that the cell cycle is halted.

There are "subtle and poorly understood" functional differences between these two cyclins.

Cyclins are molecules that manage the timing of cell cycle events.

Cyclins are generally very different from each other in primary structure, or amino acid sequence.

There are also several "orphan" cyclins for which no Cdk partner has been identified.

It does this by shortening the cell cycle and altering the expression of cyclins.

Studies with mutants suggest that cyclins are positive regulators of cell cycle entry.

A study in C. elegans revealed the specific roles of mitotic cyclins.

Cyclins are a group of proteins that activate kinases involved in cell division.

Cyclin dependent kinases pair up with cyclins to become operational.

Furthermore, cyclins can target Cdk1 to particular subcellular locations.

In addition to regulation by cyclins, Cdk1 is regulated by phosphorylation.

Cyclin D is one of the major cyclins produced in terms of its functional importance.

Cyclins are named because they are created or destroyed at predetermined points within the cell cycle.

The cyclins are necessary for the kinase subunit to function with the appropriate substrate.

Cyclins were originally named because their concentration varies in a cyclical fashion during the cell cycle.

The presence of G cyclins coordinate cell growth with the entry to a new cell cycle.

There are two main groups of cyclins:

Like other cyclins, they function by binding and activating cyclin-dependent kinase.

Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins.

In yeast, expression of any of the three G1 cyclins triggers cell cycle entry.

Like all cyclins, levels of cyclin B1 oscillate over the course of the cell cycle.

He also found that cyclins are present in vertebrate cells where they also regulate the cell cycle.