cyclin

Generally, cyclin D1 is expressed but it may not be required.

At the same time there was a substantial decrease in the level of cyclin D1.

In general levels of p53 and cyclin B are negatively correlated.

These rare patients can be identified through their elevated cyclin B levels.

It reduces the growth of new cells by inhibiting cyclin D1.

Depending on the cyclin, various portions of the cell cycle are affected.

Wild-type p53 have been shown to suppress cyclin B1 expression.

Somehow, a signal that has yet to be identified spurs the production of cyclin in the cell.

Another important function of the cyclin B1-Cdk1 complex is to break down the nuclear envelope.

Cyclin B plays in integral role in many types of cancer.

However not all cancers which overexpress cyclin B are more aggressive.

The protein that blocks the cycle of cyclin accumulation was discovered recently and named p21.

In addition, the following human proteins contain a cyclin domain:

The scientists named the mysterious protein "cyclin," because it rose and fell with the cell cycle.

However, the cytoplasmic expression of cyclin D1 is similar to that of p27.

One may speculate that the cdk4 is involved, since p27 has a preferential affinity to the cyclin D-cdk4 complex.

This virus expresses a viral cyclin which builds a complex with Cdk6.

In this way, cyclin D acts as a mitogenic signal sensor.

This is achieved by growth factor-induced expression of cyclin D proteins.

Cyclin B1 is a regulatory protein involved in mitosis.

Most obviously, Cdk1 is regulated by its binding with its cyclin partners.

So one protective mechanism that cells devised is to block a cyclin and stop dividing.

CDK and cyclin together drive the cycle from one phase to the next.

The most studied homologues of cyclin D are found in yeast and viruses.

Among these carcinomas, cyclin E appears to be more important in stomach and colon cancer.