The territory size for the Great Plains wolf depends on the type and density of prey.

By the 1930s, Great Plains wolves were extirpated almost eliminated completely, in much of the western United States.

In Wisconsin and Michigan, the Great Plains wolf was eradicated by the mid- 1960s.

The historic range of the Great Plains wolf was throughout the United States and the southern regions of Canada.

Typical prey for the Great Plains wolf consists of white-tailed deer, moose, beaver, snowshoe hare, and smaller birds and mammals.

The Retired enclosure currently houses Shadow and Malik, two Arctic wolves and Grizzer, a Great Plains wolves.

Like all wolves, the Great Plains wolf is a very social animal that communicates using body language, scent marking and vocalization with an average pack size of five to six wolves.

The Great Plains wolf (Canis lupus nubilus), also known as the Buffalo wolf, is the most common subspecies of the gray wolf in the continental United States.

However, the Northern Rocky Mountains wolf was not, at the time of the initial drafting, recognized as a legitimate subspecies, so the wolves involved in the plan were instead the Great Plains wolf and the Mackenzie Valley wolf.

The Great Plains wolf is found in the Eastern distinct population segment (DPS) categorized under the Endangered Species Act which is now awaiting new legislation to completely remove it from the endangered species list.

Coyotes have also been known, on occasion, to mate with wolves, mostly with eastern subspecies of the grey wolf such as the Great Plains Wolf, though this is less common than with dogs, due to the wolf's hostility to the coyote.

In the Animal Planet program, reports in Virginia have suggested that many of the Great Plains wolves in parts of the United States, including those migrating into said state, are diminishing in population due to a recent increase of crossbreeding with coyotes.

In the Journal of Mammalogy by Christine Bozarth of the Smithsonian Conservation Biology Institute, DNA studies revealed that coyotes moving into Northern Virginia stopped along their route to breed with the Great Plains wolves migrating south.

The Great Plains wolf (Canis lupus nubilus), also known as the Buffalo wolf, is the most common subspecies of the gray wolf in the continental United States.