Rosenthal fibers

Rosenthal fibers appear not to be present in healthy people, but occur in specific diseases, like some forms of cancer.

There is often presence of Rosenthal fibers, eosinophilic granular bodies and microcysts.

The Rosenthal fibers found in Alexander disease are not distributed in the same areas or as concentrated when compared to other diseases and disorders.

The destruction of white matter in the brain is accompanied by the formation of fibrous, eosinophilic deposits known as Rosenthal fibers.

Mutations in the coding region of GFAP have been shown to contribute to the accumulation of Rosenthal fibers.

The cellular mechanism of the disease is the presence of cytoplasmic accumulations containing GFAP and heat shock proteins, known as Rosenthal fibers.

Instead, the unifying feature among all Alexander disease cases is the presence of abnormal protein aggregates known as "Rosenthal fibers" throughout certain regions of the brain and spinal cord (central nervous system [CNS]).