It was extended northward from Milwaukee to Green Bay along what is generally its present-day route and southward from Racine to the Illinois state line.

It is located at the intersection of Ulao Road and the old Chicago and Northwestern railroad running from Milwaukee to Green Bay.

The trail began its modern day service in 1836 when stagecoaches were used to carry passengers from Chicago to Green Bay with intermediate stops.

Prior to the arrival of white settlers, the son of Chief Black Hawk supposedly camped in the vicinity while blazing a trail from Milwaukee to Green Bay.

The portion of Interstate 43 from Milwaukee to Green Bay was originally numbered as Interstate 57.

Necessary upgrades must be made before any signage changes can happen, but the entire length from Milwaukee to Green Bay is expected to become an Interstate.

The new Interstate route would roughly parallel Interstate 43, which runs north-south along Lake Michigan from Milwaukee to Green Bay, where the two interstates would meet.

Previously, the center of Thiensville's commercial activity was located to the east in what is now the Green Bay Road Historic District.

Gov. Scott Walker announced plans to turn state Highway 41 from Milwaukee to Green Bay into a new interstate.

Almost all stores carrying the Pick 'n Save banner are located south and east of a line from Madison to Green Bay, Wisconsin.