Its next closest relatives are the New World Colombian weasel (Mustela felipei) and the Amazon weasel (Mustela africana).

Colombian weasel (Mustela felipei), also known as the Don Felipe's weasel, is a very rare species of weasel only known with certainty from the departments of Huila and Cauca in Colombia and nearby northern Ecuador (where only known from a single specimen).

Colombian weasel (Mustela felipei), also known as the Don Felipe's weasel, is a very rare species of weasel only known with certainty from the departments of Huila and Cauca in Colombia and nearby northern Ecuador (where only known from a single specimen).