Auer rods

I- Rare cases with less than 5% blast will present with auer rods.

Auer rods, which may be detected in mature neutrophils.

Myeloblasts of medium size, occasionally with Auer rods.

Myeloblasts that may have azurophilic granules and/or Auer rods.

Auer rods may be seen.

Auer rods are not present.

This term is applied to these blast cells because of the presence of numerous Auer rods in the cytoplasm.

Auer rods in myeloblasts.

Larger Auer rods than in other types of AML.

Rare Auer rods.

The accumulation of these Auer rods gives the appearance of a bundle of sticks, from which the cells are given their name.

The eponymous Auer rods are named after him, which are rod-shaped inclusions in the cytoplasm of myeloblasts.

Auer rods are clumps of azurophilic granular material that form elongated needles seen in the cytoplasm of leukemic blasts.

This is further characterized histologically by the presence of Auer rods and epigenetically by lysine acetylation on residues 24 and 43.

In acute myeloblastic leukemia (M0), the blasts are agranular and nonreactive when stained for myeloperoxidase activity, and Auer rods are not seen.

They are also used to distinguish the pre-leukemia myelodysplastic syndromes: refractory anemia with excess blasts 2 (which has Auer rods) from RAEB 1 (which does not).

In straightforward cases, the presence of certain morphologic features (such as Auer rods) or specific flow cytometry results can distinguish AML from other leukemias; however, in the absence of such features, diagnosis may be more difficult.

Auer rods; absence of ringed sideroblasts; abnormal localization or immature granulocyte precursors in bone marrow section all or mostly abnormal karyotypes or complex marrow chromosome abnormalities and in vitro bone emarrow culture-leukemic growth pattern. "