On the other hand, recent research has been exploring new ways of administering papain for wound debridement.

Like most military operatives who worked alone or in pairs, Ty had been trained in field medicine and was experienced in wound debridement.

Bradley et al. have stated that it is "unclear whether wound debridement is a beneficial process that expedites healing".

Maggot therapy for wound debridement is a traditional therapy which was in recent years approved by the FDA.

For wounds/lacerations, it is available in the United States by prescription as a wound debridement and cleansing system under the brand name Irrisept.

Main article: Maggot therapy Live maggots of certain species of flies have been applied since antiquity as an effective means of wound debridement.

This is an important distinction, as most other major varieties of myiasitic fly larvae attack both live and dead wound tissue indiscriminately, effectively negating their benefit in non-harmful wound debridement.

It has been used (without regulation) for wound debridement for many years, but in the USA in 2008 it was brought under regulation by the U.S. Food and Drug Administration and removed from sale for this purpose, following reports of adverse effects.