TD is defined as three or more unformed stools in 24 hours passed by a traveler, commonly accompanied by abdominal cramps, nausea, and bloating.

Recommended initial dose: two capsules (4 mg) by mouth every 4 hours, followed by one capsule (2 mg) by mouth after each unformed stool.

It may also be described as an abnormal increase in the amount of fluid in the stool and the passage of more than 3 unformed stools during a 24-hour period.