unconjugated bilirubin

The level of unconjugated bilirubin in the blood is elevated.

This unconjugated bilirubin is not soluble in water.

This allows the excretion of unconjugated bilirubin in bile.

The unconjugated bilirubin still enters the liver cells and becomes conjugated in the usual way.

Most infants develop visible jaundice due to elevation of unconjugated bilirubin concentration during their first week.

The heme is then turned into unconjugated bilirubin in the reticuloendothelial cells of the spleen.

Gilbert's syndrome produces an elevated level of unconjugated bilirubin in the bloodstream but normally has no serious consequences.

A major characteristic is jaundice, supposedly caused by elevated levels of unconjugated bilirubin in the bloodstream (hyperbilirubinemia).

Unconjugated bilirubin is very hydrophobic and relies on transportation on albumin that is circulating in the blood.

The system's cells convert the protoporphyrin into unconjugated bilirubin that passes through the circulatory system bound to protein, particularly albumin.

Because the unconjugated bilirubin is not water-soluble, one will not see an increase in bilirubin in the urine.

Raised liver transmainases with no rise in conjugated and unconjugated bilirubin are sometimes detectable, although the absence of such does not exclude the diagnosis.

This is why addition of high concentration hydrophobic drugs (certain antibiotics, diuretics) and high free fatty acids can cause elevated unconjugated bilirubin.

Neonates also have a low amount of functional UDP-glucuronyl-transferase and can have elevated unconjugated bilirubin since conjugated is limited.

People with GS predominantly have elevated unconjugated bilirubin, while conjugated bilirubin is usually within the normal range and is less than 20% of the total.

Relatively low activity of the enzyme glucuronosyltransferase which normally converts unconjugated bilirubin to conjugated bilirubin that can be excreted into the gastrointestinal tract.

However, unconjugated bilirubin also reacts slowly with diazosulfanilic acid, so that the measured indirect bilirubin is an underestimate of the true unconjugated concentration.

This "conjugated" (attached) bilirubin is called direct bilirubin; unconjugated bilirubin is called indirect bilirubin.

Sulfonamides are contraindicated in infants less than 2 months old (exception when used with pyrimethamine in treating toxoplasmosis) as they increase unconjugated bilirubin leading to kernicterus.

The disorder results in an inherited form of non-hemolytic jaundice, which results in high levels of unconjugated bilirubin and often leads to brain damage in infants.

Autosomal recessive knockouts of UDP-glucuronyl-transferase itself can lead to Crigler-Najjar Syndrome and elevations of unconjugated bilirubin.

However, in disorders involving hemolytic anemia, an increased number of red blood cells are broken down, causing an increase in the amount of unconjugated bilirubin in the blood.

The liver is responsible for clearing the blood of unconjugated bilirubin and about 30% of bilirubin is taken up by a normal liver each pass through the liver.

Our experimental work on sedimentation was done with unconjugated bilirubin (UCB) and we used DMSO instead of its deuterated analogue, (C 2H 3 ) 2 SO.

Bilirubin transport across the hepatocyte may be impaired at any point between the uptake of unconjugated bilirubin into the cell and transport of conjugated bilirubin into biliary canaliculi.