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Further damage occurs in the white matter of the uncinate fasciculus.
They also showed less developed white matter connections between different areas in their cerebral cortices, particularly the uncinate fasciculus.
The greater left than right fractional anisotropy of the uncinate fasciculus is missing in those with schizophrenia.
Among the alterations of both synaptic and global structure, the most significant abnormalities are observed in the uncinate fasciculus.
The function of the uncinate fasciculus is not known, though it is traditionally considered to be part of the limbic system.
The uncinate fasciculus connects it with the amygdala, temporopolar proisocortex and anterior most part of the superior temporal gyrus.
The uncinate fasciculus has the longest period of development in terms of fractional anisotropy as it alone amongst the major white fibre tracks continues to develop beyond the age of 30.
The uncinate fasciculus is a hook-shaped bundle that links the forward portions of the temporal lobe with the inferior frontal gyrus and the lower surfaces of the frontal lobe.
Abnormalities within the fiber bundles of the uncinate fasciculus associate with social anxiety, Alzheimer's disease, bipolar disorder, and depression in the elderly that had first had it in adolescence or early adulthood.
The uncinate fasciculus on the left side shows greater fractional anisotropy (a measure of microstructural integrity) than on the right, and this has been argued to possibly link to the left hemispheric specialization for language.
People scoring 25 in the Psychopathy Checklist Revised, with an associated history of violent behavior, appear to have significantly reduced microstructural integrity in their uncinate fasciculus - white matter connecting the amygdala and orbitofrontal cortex.
The patient's MRI revealed damage to the right ventral frontal cortex and underlying white matter, including the uncinate fasciculus, a band of fibres previously thought to mediate retrieval of specific events from one's personal past.
In 10 year-old children who have suffered socioemotional deprivation, the left uncinate fasciculus shows reduced fractional anisotropy compared to that in other children, and this might underlie their cognitive, socioemotional, and behavioral difficulties.
Its fibers are near to but can be distinguished by MRI tractography from adjacent fiber bundles such as the uncinate fasciculus, the external capsule, the arcuate fascicle, and the medial, inferior and superior longitudinal fascicles.
The uncinate fasciculus is a white matter tract in the human brain that connects parts of the limbic system such as the hippocampus and amygdala in the temporal lobe with frontal ones such as the orbitofrontal cortex.
The capacity for autonoetic self-awareness that is re-experiencing previous events as part of one's past as a continuous entity across time has been linked to the right uncinate fasciculus as has proficiency in auditory-verbal memory and declarative memory to the integrity of the left uncinate fasciculus.