ubiquitin ligase

E6-AP is involved in the ubiquitin ligase pathway.

An E3 ubiquitin ligase targets specific protein substrates for degradation by the proteasome.

Each E3 ubiquitin ligase binds to a particular set of substrates, causing their ubiquitination.

(A) Activation of a specific E3 molecule creates a new ubiquitin ligase.

The net result is that this ubiquitin ligase complex is important for limb outgrowth in embryos.

The notion that Siah, a putative ubiquitin ligase, would have other roles in cell signaling is not surprising.

E6 in association with host E6-associated protein, which has ubiquitin ligase activity, acts to ubiquitinate p53, leading to its proteosomal degradation.

The majority of the kinases involve ubiquitin ligase and culminate in the degradation of proteins.

Lck can also be inhibited by Cbl ubiquitin ligase, which is part of the ubiquitin-mediated pathway.

Mdm2 also has E3 ubiquitin ligase activity toward p53, and promotes its exportation from the cell nucleus to the cytoplasm for degradation.

It is an E3 ubiquitin ligase which is necessary for autophagy due to its role in autophagosome elongation.

MDM2 (mouse double minute 2, ubiquitin ligase)

Highwire (Hiw) is an E3 ubiquitin ligase protein associated with neuromuscular junction growth.

The systematic name of this enzyme class is calmodulin:ubiquitin ligase (AMP-forming).

These complexes bear ubiquitin ligase activity in a substrate-independent in vitro assay (Fig.

The E3 Ubiquitin ligase enzyme is the main component that provides specificity in the regulation of immune signaling pathways.

EPM2B encodes the protein malin, an E3 ubiquitin ligase.

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

In addition, CHIP possesses E3 ubiquitin ligase activity and promotes ubiquitylation.

Furthermore TRIM22 is located in the nucleus and therefore may function as a nuclear E3 ubiquitin ligase.

In general, this step requires the activity of one of the hundreds of E3 ubiquitin-protein ligases (often termed simply ubiquitin ligase).

In addition, miR-137 targets Mib1 (Mind Bomb-1), a ubiquitin ligase known to be important for neurogenesis and neurodevelopment.

Thus, CSN deficiency appears to stimulate Pcu3p-associated ubiquitin ligase activity in vitro .

This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex.

Mdm2 also acts as an E3 ubiquitin ligase, targeting both itself and p53 for degradation by the proteasome (see also Ubiquitin).