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Increased indirect or total bilirubin may indicate:
Increased total bilirubin (TBIL) causes jaundice, and can indicate a number of problems:
Indican interferes with many commercial procedures for measuring total bilirubin which can be a problem for renal failure patients where blood indican levels are raised.
The level of total bilirubin is often further increased if the blood sample is taken after fasting for two days, and a fast can therefore be useful diagnostically.
Total bilirubin ("TBIL") measures both BU and BC.
Neonatal cholestasis defines persisiting conjugated hyperbilirubinemia in the newborn with conjugated bilirubin levels exceeding 15% (5,0 mg/dL) of total bilirubin level.
Serum activities of asparate transcininase alanine transaminase, amylase, lipase, the concentrations for total bilirubin, glucose, potassium, sodium, creatinin, and the prothrombin time were in the normal range.
Total bilirubin and direct bilirubin levels are measured directly in the blood, whereas indirect bilirubin levels are derived from the total and direct bilirubin measurements.
Recent research has indicated that in the absence of liver disease, individuals with high levels of total bilirubin may experience various health benefits exceeding those with lower levels of bilirubin.
Total bilirubin is now often measured by the 2,5-dichlorophenyldiazonium (DPD) method, and direct bilirubin is often measured by the method of Jendrassik and Grof.
Liver failure was defined as present if total bilirubin was 2.0 mg/dl or greater, and either the alkaline phosphatase or a transaminase level was greater than twice normal, in the absence of confounding disease.
If the total bilirubin does in fact increase while fasting, the patient can then be given low doses of phenobarbital when fasting has ended, and following samples should show a decrease in total bilirubin toward normal levels.
Plasma biochemical analyses also included determination of concentrations of sodium, potassium, chloride, carbon dioxide, urea nitrogen (BUN), creatinine, calcium, glucose, phosphorus, total bilirubin, cholesterol, uric acid, total protein, albumin, globulin, alkaline phosphatase, SGOT, SGPT.
The FibroTest score is calculated from the results of a six-parameter blood test, combining six serum markers with the age and gender of the patient: Alpha-2-macroglobulin, Haptoglobin, Apolipoprotein A1, Gamma-glutamyl transpeptidase (GGT), Total bilirubin, and Alanine transaminase (ALT).