Tobacco amblyopia is a form of toxic amblyopia caused by tobacco containing cyanide.

Tobacco amblyopia is marked by a gradual impairment of vision characterised by visual field defects and hindered central vision.

However, tobacco amblyopia is a rare condition, and it is yet unclear whether it represents a peculiar B deficiency that is resistant to treatment with cyanocobalamin.

Furthermore, IM administration of OHCbl is also the preferred treatment for pediatric patients with intrinsic cobalamin metabolic diseases; vitamin B-deficient patients with tobacco amblyopia due to cyanide poisoning; and patients with pernicious anemia who have optic neuropathy.

If ever I am stricken with smoker's heart, or staggers, or tobacco amblyopia, or any other of the cheery things which doctors predict for the devotee of the weed, I shall feel that I sowed the seeds of it that summer in that little clearing overlooking the sea.